EDITORIAL
| San Francisco EAB/Special Feature Sections for 2007 and 2008 Trevor Laird 165-165 |
| Full: PDF (16 K) |
HIGHLIGHTS FROM THE LITERATURE
| Some Items of Interest to Process R&D Chemists and Engineers Trevor Laird*, Mark McLaughlin, Silvina García Rubio, Ulf Tilstam, Octavio Augusto Ceva Antunes, Ganapati D. Yadav, and Andrei A. Zlota 166-177 |
| Full: PDF (276 K) |
HIGHLIGHTS FROM THE PATENTS
| A Review of U.S. Patents in the Field of Organic Process Development Published during July to September 2006 Keith Turner 178-189 |
| Full: PDF (267 K) |
FULL PAPERS
| Process Development and Scale-Up of PPAR α/γ Dual Agonist Lobeglitazone Sulfate (CKD-501) Hong Woo Lee, Joong Bok Ahn, Sung Kwon Kang, Soon Kil Ahn, and Deok-Chan Ha 190-199  |
| Full: PDF (164 K) |
| Practical Synthesis of a Heterocyclic Immunosuppressive Vitamin D Analogue Juergen Westermann, Matthias Schneider, Johannes Platzek, and Orlin Petrov 200-205  |
| Full: PDF (102 K) |
| A Concise Synthesis of Racemic 1-(6,7-Dimethoxy-2-naphthyl)-1-(1H-imidazol-4-yl)-2-methylpropan-1-ol for a Potent C17,20-Lyase Inhibitor Jun-ichi Kawakami, Kazuhiro Kimura, and Masayoshi Yamaoka 206-209  |
| Full: PDF (78 K) |
| Borane-THF: New Solutions with Improved Thermal Properties and Stability Mark Potyen, Kanth V. B. Josyula, Mike Schuck, Sean Lu, Peng Gao, and Chris Hewitt 210-214  |
| Full: PDF (77 K) |
| Dynamic Biphasic Counterion Exchange in a Configurationally Stable Aziridinium Ion: Efficient Synthesis and Isolation of a Koga C2-Symmetric Tetraamine Base Matthew J. Frizzle, Sebastien Caille, Teresa L. Marshall, Kenneth McRae, Kelly Nadeau, Gary Guo, Steven Wu, Michael J. Martinelli, and George A. Moniz 215-222  |
| Full: PDF (368 K) |
| A Systematic Approach for the Development of Liquid Chromatographic Methods Attilio Ceccato, Esther Reus, Willy Brione, Anne Vanderweyen, Annick Flament, Gabriel Caliaro, and Ulf Tilstam 223-228  |
| Full: PDF (128 K) |
| Water Activity-Mediated Control of Crystalline Phases of an Active Pharmaceutical Ingredient Narayan Variankaval, Claire Lee, Jing Xu, Ralph Calabria, Nancy Tsou, and Richard Ball 229-236  |
| Full: PDF (900 K) |
| Development of a Concise Scaleable Synthesis of 2-Chloro-5-(pyridin-2-yl) Pyrimidine via a Negishi Cross-Coupling Carlos Pérez-Balado, Albert Willemsens, Dominic Ormerod, Wim Aelterman, and Narda Mertens 237-240  |
| Full: PDF (65 K) |
| Expedient Synthesis of MLN1251, A CCR5 Antagonist for Treatment of HIV Magnus Rönn, Quentin McCubbin, Steve Winter, Melanie K. Veige, Neil Grimster, Tony Alorati, and Louis Plamondon 241-245  |
| Full: PDF (68 K) |
| Development of a Practical Synthesis of STA-5312, a Novel Indolizine Oxalylamide Microtubule Inhibitor Hao Li, Zhiqiang Xia, Shoujun Chen, Keizo Koya, Mitsunori Ono, and Lijun Sun 246-250  |
| Full: PDF (72 K) |
REVIEWS
| Cyclopentyl Methyl Ether as a New and Alternative Process Solvent Kiyoshi Watanabe, Noriyuki Yamagiwa, and Yasuhiro Torisawa 251-258  |
| Full: PDF (193 K) |
| Recent Advances in Developing Chemoenzymatic Processes for Active Pharmaceutical Ingredients Junhua Tao, Lishan Zhao, and Ningqing Ran 259-267  |
| Full: PDF (189 K) |
TECHNICAL NOTES
| An Improved Synthesis of Memantine Hydrochloride: Anti-Alzheimer's Drug Jambula Mukunda Reddy, Ganji Prasad, Veeramalla Raju, Mylavarapu Ravikumar, Vurumidi Himabindu, and Ghanta Mahesh Reddy 268-269  |
| Full: PDF (31 K) |
| Investigation of the Stability of the Corey-Kim Intermediate Russell D. Cink, Gilles Chambournier, Herman Surjono, Zhenglong Xiao, Steve Richter, Marius Naris, and Ashok V. Bhatia 270-274  |
| Full: PDF (136 K) |
| Practical Synthesis of 3-Amino-4,5-dimethylisoxazole from 2-Methyl-2-butenenitrile and Acetohydroxamic Acid John E. Tellew, Leslie Leith, and Arvind Mathur 275-277  |
| Full: PDF (88 K) |
| Preparation of 4-Vinylphenol Using pHCA Decarboxylase in a Two-Solvent Medium Arie Ben-Bassat, Sabine Breinig, Grace A. Crum, Lixuan Huang, Amee La Bonte Altenbaugh, Nancy Rizzo, Robert J. Trotman, Todd Vannelli, F. Sima Sariaslani, and Sharon L. Haynie 278-285  |
| Full: PDF (373 K) |
| Oligomerisation of Alkenes by Radical Initiation Michele Cowley 286-288  |
| Full: PDF (30 K) |
COMMUNICATIONS TO THE EDITOR
| Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram: A Key Intermediate for Escitalopram Chandrashekar R. Elati, Naveenkumar Kolla, Pravinchandra J. Vankawala, Srinivas Gangula, Subrahmanyeswarara Chalamala, Venkatraman Sundaram, Apurba Bhattacharya, Himabindu Vurimidi, and Vijayavitthal T. Mathad 289-292  |
| Full: PDF (83 K) |
ADDITIONS & CORRECTIONS
| Energy Efficiency in Chemical Reactions: A Comparative Study of Different Reaction Techniques Mark J. Gronnow, Robin J. White, James H. Clark, and Duncan J. Macquarrie 293-293 |
| Full: PDF (18 K) |
| Eutectic Composition of a Chiral Mixture Containing a Racemic Compound Yaling Wang, Rosario LoBrutto, Robert W. Wenslow,and, and Ivan Santos 293-293 |
| Full: PDF (18 K) |
BOOK REVIEWS
| Pharmaceutical Substances 2.4 By Axel Kleeman, Juergen Engel, Bernhard Kutscher, and Dietmar Reichert. Thieme: New York, Stuttgart. 2006. Online Product Available by Annual Subscription at www.thieme-chemistry.com. Price on Application Peter L. Spargo 294-294 |
| Full: PDF (20 K) |
| Thiophenes. By Salo Gronowitz and Anna-Britta Hörnfeldt. Elsevier: Oxford, 2004. xxii + 964 pp. $323.00. ISBN 0-1230-3953-3 J. B. Sweeney 294-295 |
| Full: PDF (20 K) |
| Synthesis of Acetylenes, Allenes and Cumulenes: Methods and Techniques, 1st ed by Lambert Brandsma. Elsevier Academic Press: Boston, Amsterdam. 2004. xxxii + 469 pp. $249. ISBN 0-1212-5751-7. Roderick Bates 295-296 |
| Full: PDF (20 K) |
| Biocatalysis in the Pharmaceutical and Biotechnology Industries Edited by Ramesh N. Patel. CRC Press: Boca Raton, FL; London. 2007. 893 pp. $169.95, £99. ISBN-10 0-8493-3732-1. T. Laird 296-296 |
| Full: PDF (20 K) |